Archives
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To ensure the induction of CYP enzymes by
2022-05-16
To ensure the induction of CYP enzymes by several inducers, specific monooxygenase activities of variously induced, uninduced and pooled liver microsomes were compared (Fig. 3). Although 3-MC, phenobarbital, acetone, and dexamethasone could induce CYP1A-, CYP2B-, CYP2E1-, and CYP3A-selective enzyme
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Recently we indicated that cell motility was regulated by
2022-05-16
Recently, we indicated that cell motility was regulated by the different induction of GPR120 and GPR40 in liver epithelial WB-F344 CKI 7 dihydrochloride sale treated with chemical agents. The cell motility of WB-F344 cells was stimulated by phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) w
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br Clinical assessment of iron chelation
2022-05-16
Clinical assessment of iron chelation Towards the new concept of conservative iron chelation: iron scavenging and redeployment For any chelator to be of clinical value in disorders of regional siderosis they ought to be endowed with a requisite accessibility to the relevant sites and different
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br Materials and methods This is a retrospective case
2022-05-16
Materials and methods This is a retrospective case-controlled study. The cases were selected based on the presence or absence of preeclampsia. Women enrolled in the study delivered singleton pregnancies at our institution from June 2003 to July 2004. Preeclampsia is defined as elevated blood pres
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br Discussion The LISA analysis indicated that
2022-05-16
Discussion The LISA analysis indicated that HIV was geographically clustered in the north-west districts of Amhara Region. A high rate of HIV infection was found in Metema and Mirab Armacho districts, which share borders with Eretria and Sudan. Various studies have linked risk of infectious disea
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KDM D also known as JARID
2022-05-16
KDM5D (also known as JARID1D or SMCY) is encoded on the Y chromosome and until now it has been implicated in prostate cancer invasion and metastasis [42], spermatogenesis [43], and sex-specific tissue transplantation rejection [44]. KDM5D acts as a direct epigenetic modulator, and as one of the four
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The HIF complex was initially identified as
2022-05-16
The HIF complex was initially identified as an important component of the cell machinery involved in the response and Sunitinib to hypoxia (Semenza, 2001). Further studies have shown that HIF can also modulate whole-body energy homeostasis by controlling hypothalamic neurons (Varela et al., 2017, Zh
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Hexokinases HXKs are major regulatory
2022-05-16
Hexokinases (HXKs) are major regulatory enzymes in sugar metabolism and in sugar sensing in plants (Claeyssen and Rivoal, 2007, Granot et al., 2013, Sheen, 2014, Aguilera-Alvarado and Sánchez-Nieto, 2017). HXK can phosphorylate both glucose and fructose to respective hexose-6-phosphates as a first s
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While phosphorylation site motifs are typically described
2022-05-13
While S-Adenosylhomocysteine mg site motifs are typically described in terms of residues that promote phosphorylation, negatively selected residues can also be an important component of substrate recognition. Such ‘forbidden’ resides can act as a filter to prevent phosphorylation of a site by the ‘
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br Author Contributions br Acknowledgments We thank
2022-05-13
Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members
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Toxoplasma gondii is an exceptionally tractable apicomplexan
2022-05-13
Toxoplasma gondii is an exceptionally tractable apicomplexan parasite that expresses a limited yet representative subset of apicomplexan cyclase orthologs, making it an ideal model for investigating cyclic nucleotide signaling in Apicomplexa. Of the five putative nucleotide cyclases, only TgACα1 and
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Having identified initial leads and
2022-05-13
Having identified initial leads and (), further lead optimization was initiated on B- and C-rings to afford compounds with improved potency. Initial set of substituted imidazole-biphenyl-carboxylic Cepharanthine australia derivatives – and () were evaluated for GSNOR potency. Among this, fluoro,
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br Material and methods br Results and discussion Unlike
2022-05-13
Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of dexamethasone acetate biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, are called
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Phagocytosis was observed at min after mixing macrophages wi
2022-05-13
Phagocytosis was observed at 60 min after mixing macrophages with microbes (A). The phagocytosis ability (PA) and phagocytosis index (PI) values of the macrophages engulfing the bacteria measured in flow cytometer were shown in histograms (B). Statistical analyses revealed that both the PA and PI va
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Wasting syndrome is a common complication
2022-05-13
Wasting syndrome is a common complication of HIV infection and is marked by progressive weight loss and weakness, often associated with fever (Weinroth et al., 1995). Fever is a highly complex process initiated by the action on the prostaglandin e1 thermosensitive cells of a number of endogenous py