Archives
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The majority of APC C subunits form
2021-05-11
The majority of APC/C subunits form a giant scaffold, which was originally named the arc lamp, based on its shape when viewing APC/C from one side (Figure 1 and Box 1) [24]. The scaffold consists of two modules: the TPR lobe resembles the curved post and lamp, and the platform resembles the tyrosine
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csf-1r br Materials and methods br Results br Discussion
2021-05-11
Materials and methods Results Discussion Drug of abuse induces widespread csf-1r changes in the molecular and cellular functions in circuits between VTA and its neighbored regions such as NAC, and amygdala. It is belived that these changes result behavioral phenotype that characterize addi
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Furthermore Survivin is a member of
2021-05-11
Furthermore, Survivin is a member of the inhibitor of apoptosis family. IR induces a rapid nuclear accumulation of survivin and subsequent phosphorylation of the protein in the nucleus. Co-immunoprecipitation and immunofluorescence co-localization analyses revealed an interaction among survivin, Ku7
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Our finding that the ATRX DAXX H complex promotes a
2021-05-11
Our finding that the ATRX-DAXX-H3.3 complex promotes a form of HR is likely to have important implications for our understanding of the ALT recombination process that takes place at telomeres. We were surprised to observe that ATRX promotes a form of HR, since loss of the ATRX-DAXX-H3.3 complex is n
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br Phenotypic responses alkylation induced cell death and mu
2021-05-11
Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla
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STRING protein interactions were used to highlight
2021-05-11
STRING protein interactions were used to highlight enzymes directly associated with DHODH (Fig. 10) (Szklarczyk et al., 2015). The reported protein-protein associations are primarily within the de novo nucleotide synthesis pathways (CAD, carbamoyl phosphate synthetase 1, uridine monophosphate synthe
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Previous and ongoing clinical trials have been summarized
2021-05-11
Previous and ongoing clinical trials have been summarized in a recent review (Siaw-Debrah et al., 2017). To our knowledge, there are no ongoing or completed clinical trials focusing on cytokines in ICH. Published studies have focused mainly on cytokine changes in ICH patients (summarized in Table 3)
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br Results and discussion Compounds
2021-05-10
Results and discussion Compounds were tested for their binding affinity to human CRTH2 in a radioligand binding assay (3H-PGD2) using CHO cells stably transfected with human CRTH2. In addition, these compounds were assessed for their functional activity in PGD2 driven Ca2+ flux in KB8 cells expre
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Notochord is a transient structure differentiating at early
2021-05-10
Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated nitric oxide synthase inhibitor surrounded by a unique ECM structure improperly called notochordal BM. As i
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In recent years neuroimaging studies have
2021-05-10
In recent years, neuroimaging studies have increasingly demonstrated acute effects of THC on Murine sale function, the vast majority of them involving a cognitive challenge (Bossong et al., 2014b). For example, without affecting performance accuracy, THC caused reductions in activity during encodin
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There is a large interindividual difference
2021-05-10
There is a large interindividual difference in intestinal cholesterol ghrelin receptor of cholesterol that is mainly due to genetic variation [15], [19]. Single nucleotide variation (SNV) in NPC1L1 and, ABCG5 and ABCG8 key modulators of cholesterol influx and efflux into intestinal mucosal cells, r
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The ACC receptor family appear to be attractive targets for
2021-05-10
The ACC receptor family appear to be attractive targets for the development of novel anthelmintics. With this in mind we also tested the activity of the anthelmintics levamisole and pyrantel which activate the nematode nAChR (Martin and Robertson, 2007). We found both molecules were partial agonists
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EPAC activation in VSMCs and ECs reverses several
2021-05-10
EPAC activation in VSMCs and ECs reverses several processes involved in the development of in-stent restenosis. Of particular relevance is the ability of EPAC1 to induce SOCS3 gene expression, as SOCS3 exerts multiple protective effects in both cell types, while immunohistochemical studies have show
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The prospects of the use
2021-05-10
The prospects of the use of this novel approach for the selective local thermo-activation of enzymes include biomedical and biotechnological applications. As NPs could be engineered to gain access to uncouplers of oxidative phosphorylation through the endosomal compartment [47] or through non-endoc
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hematopoietic stem cells br Acknowledgments br Introduction
2021-05-10
Acknowledgments Introduction Endothelin receptors Shortly after the discovery of ET‐1, two types of seven transmembrane G protein‐coupled receptors were cloned called endothelin receptor A (ETA) (Arai et al., 1990) and ETB (Sakurai et al., 1990). The affinity of the ETA receptor for ET-3 is