Archives
-
Malonic acid GnRH ant have been designed to obtain pharmacol
2022-06-16
GnRH-ant have been designed to obtain pharmacological compounds to block the pituitary–gonadal axis without the undesirable flare effect exerted by GnRH itself or by the GnRH-a (see Section 2.2). GnRH-ant competitively block the binding of GnRH to GnRHRs (Schally, 1999; Tan & Bukulmez, 2011); they p
-
Post translational modifications of the GR can alter
2022-06-16
Post-translational modifications of the GR can alter the transcriptional effects of GR activation [31], and may provide a mechanism for the interactions between cell signaling pathways and GR-mediated transcriptional activity. Dex-BSA treatment reportedly increased p38 MAPK activation in CD14-positi
-
W-7 hydrochloride Numerical models of blood regulation provi
2022-06-15
Numerical models of blood regulation provide insight into the interaction of the cellular-level and macro-scale phenomena studied in silico, a term referring to computer simulations of the dynamics of complex biological systems as opposed to in vivo or in vitro experimental studies. These in silico
-
Ryuvidine receptor The present study also demonstrated that
2022-06-15
The present study also demonstrated that edoxaban inhibited both free and clot-bound FXa activity. The IC50 values for free and clot-bound FXa in this study are well consistent with Ki values for free FXa and FXa incorporated in prothrombinase complex (0.561 and 2.98nM, respectively) in our previous
-
In addition to Rabs several
2022-06-15
In addition to Rabs, several proteins have been shown to interact with Rabphilin3a, for instance the GluN2A subunit of the NMDA receptor, PSD-95 ([56,57] and references therein), Rabaptin-5, α-actinin [16] and SNAP-25 [21,23,41,61]. Only the latter has been reported to participate in the AR. Explori
-
Whereas Sororin is dispensable in the absence of Wapl overex
2022-06-15
Whereas Sororin is dispensable in the absence of Wapl [14], overexpressed Haspin only partly supports cohesion in Sororin-depleted cells. Thus, although Haspin and Sororin have functional similarities, they are not fully redundant at the centromere. Haspin may have a mitosis-specific role in maintai
-
AMG 337 Differentiation to either Th or Th cells is signific
2022-06-14
Differentiation to either Th1 or Th2 AMG 337 is significantly influenced by the relative expression of T-bet and GATA-3, respectively (Zhu et al., 2006, Jenner et al., 2009). T-bet acts as a key regulator of Th1 cell fate determination and directly activates IFN-γ and suppresses IL-4 (Szabo et al.,
-
br Acknowledgements We thank the support
2022-06-14
Acknowledgements We thank the support of the National Natural Science Foundation of China (NSFC) project 81501342 and support from the Disciplinary Group of Oncology and Immunology program of Xinxiang Medical University. Introduction First described as a new clinical entity in 1981, the Acqui
-
br Recent insights into EAAT structure function
2022-06-14
Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen
-
br Discussion RBCs possess a much simpler composition and
2022-06-14
Discussion RBCs possess a much simpler composition and structure than other eukaryotic Pyr3 and can therefore serve as a convenient system on which to study how cell functioning relates to the molecular and supramolecular properties of its constituents. The model developed in this work is aimed
-
br Pannexins which form channels connecting cells
2022-06-14
Pannexins, which form channels connecting serine protease inhibitors with the extracellular environment, have also been studied in the setting of NASH. When open these channels participate in inflammatory processes. A decrease in lobular inflammation and oxidative stress was observed in mice with
-
br Summary br Conflict of interest br Acknowledgments This
2022-06-14
Summary Conflict of interest Acknowledgments This study was supported by Grant No. 2014/13/B/NZ7/02277 from the National Science Centre, Poland. Introduction Progesterone (P) is an anticonvulsant hormone (Backstrom et al., 1984, Herzog, 1995, Herzog, 1999, Frye et al., 2000, Reddy, 2002
-
Introduction G quadruplexes are therapeutically
2022-06-14
Introduction G-quadruplexes are therapeutically important non-canonical nucleic ubiquitin e3 ligase structures that are formed by a planar assembly of four guanines, termed G-tetrads (Fig. 1), in the guanine rich regions of genome [[1], [2], [3]]. As it is getting increasingly established, several
-
To date the crystal structures of
2022-06-14
To date, the crystal structures of HIV-1 IN complexed with ligands and related proteins could help us in studying the interactions between the inhibitors and IN. Until now, 114 co-crystal structures of HIV-1 IN with small molecular ligands 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,
-
The following are the supplementary data related to
2022-06-13
The following are the supplementary data related to this article. Transparency document Introduction Hypoxia is a pathological process that causes abnormal changes in metabolism, function and morphological structure of tissue because of insufficient oxygen supply. It's reported that hypoxia w
9537 records 10/636 page Previous Next First page 上5页 678910 下5页 Last page