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RDH belongs to C family
2019-07-18
RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,
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br Conclusions This study showed that in EOC cells tyrosine
2019-07-18
Conclusions This study showed that in EOC cells, tyrosine kinase receptor DDR1 was expressed mainly in EOC ha peptide with an Epithelial phenotype. The repressed expression of DDR1 in EOC cells with Mesenchymal phenotype could be due to the higher CpG methylation levels observed at the promoter
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Altogether we have shown the presence of fully methylated DA
2019-07-18
Altogether we have shown the presence of fully methylated DAPK fragments in serum of ovarian cancer patients but also of women with uterine leiomyoma. This indicates the prerequisite for the analysis of not only healthy controls but also of women with other frequent non-cancer disease for the valida
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Each nsP plays a distinct defined and
2019-07-18
Each nsP plays a distinct, defined and indispensable role in the replication of viral genome. nsP1 is a membrane associated protein which possesses S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase) and guanylyltransferase (GTase) activities to catalyze the viral RNA capping reaction
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It should also be noted that remarkable individual differenc
2019-07-18
It should also be noted that remarkable individual differences in extinguished fear bradycardia (i.e., CS+E vs. CS−E) during initial Day 2 recall test were observed, particularly within Met carriers. Exploratory analyses revealed that these individual differences were partly driven by the level of r
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Cholesterol homeostasis is maintained through a tight regula
2019-07-18
Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The tachykinin receptor of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In p
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Perturbations in cell cycle are known to
2019-07-18
Perturbations in Calcium Colorimetric Assay Kit are known to induce apoptosis. Our results show that a fraction of the DT40YB-1b+/− cells, in addition to becoming tetraploids, undergo apoptotic cell death. Similar observations linking polyploidy and apoptosis have been made in the past [23], [30],
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In all available E E structures the RING type
2019-07-18
In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans
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Concerning family A GPCRs although
2019-07-18
Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e
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The estrogenic activity of steroids with
2019-07-18
The estrogenic activity of steroids with a C19 methyl group may provide a selective advantage in estrogen physiology that is not provided by E2. In this regard, 5α-androstanediol has been proposed to be a second physiological estrogen in fetal mouse Pemetrexed disodium hemipenta hydrate for based o
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Fusion genes are formed as the result of either structural
2019-07-18
Fusion genes are formed as the result of either structural chromosomal rearrangement including, primarily, translocation, inversion, amplification and deletion, or non-structural aberrations caused by cis- and trans-splicing or transcriptional read-through. Such events are known to play important ro
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DPP is show two relevant benefits in the
2019-07-17
DPP-4is show two relevant benefits in the clinical management of type 2 diabetic patients: negligible risk of severe hypoglycemia, particularly when compared with sulphonylureas [[33], [34]], and weight neutrality, in contrast with the weight gain generally observed with insulin therapy, sulfonylure
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EBI remains an orphan GPCR and the identity and source
2019-07-17
EBI2 remains an orphan GPCR and the identity and source of its ligand are yet to be described. Molecular studies of EBI2 have suggested that this receptor has constitutive activity, similar to that observed for many herpesvirus-encoded 7TM receptors (Benned-Jensen and Rosenkilde, 2008, Rosenkilde et
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br Significance Dysregulation of dopamine homeostasis contri
2019-07-17
Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of ApexPrep DNA Plasmid Miniprep Column Only governing the synthesis, packaging, and reuptake of dopa
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Many DNA repair pathways are candidates for DPC repair Nucle
2019-07-17
Many DNA repair pathways are candidates for DPC repair. Nucleotide excision repair (NER) is widely involved in both bacteria and eukaryotes in removing cross-linked protein with low molecular weights (11kDa) (Ide et al., 2011). The predominant pathway chosen by Mouse iPSC Chemical Reprogramming Cock