• BMN 673 (Talazoparib): Precision Targeting of DNA Repair ...

  2025-09-26

  Explore how BMN 673 (Talazoparib), a potent PARP1/2 inhibitor, leverages advanced insights into PARP-DNA complex trapping and homologous recombination to revolutionize selective cancer research. This article provides a mechanistic deep dive and strategic guidance for PI3K pathway modulation and DNA repair deficiency targeting.

• Pioglitazone and PPARγ: Unlocking Immune-Metabolic Crosst...

  2025-09-25

  Explore how Pioglitazone, a PPARγ agonist, uniquely modulates immune-metabolic pathways in research, advancing understanding of insulin resistance and inflammation. Discover novel insights into macrophage polarization and beta cell protection with this comprehensive analysis.

• Sildenafil Citrate: Advanced Proteoform-Targeted Strategi...

  2025-09-24

  Explore the scientific foundations and cutting-edge applications of Sildenafil Citrate as a selective cGMP-specific phosphodiesterase type 5 inhibitor for cardiovascular research. This article uniquely integrates proteoform-targeted drug discovery, native MS insights, and vascular signaling dynamics.

• (S)-Mephenytoin as a CYP2C19 Substrate: Advancing Human I...

  2025-09-23

  Explore the application of (S)-Mephenytoin as a mephenytoin 4-hydroxylase substrate in innovative human intestinal organoid models for pharmacokinetic research. This article examines technical considerations and scientific advancements in CYP2C19 substrate utilization for in vitro CYP enzyme assay development.

• The canonical binding sites to which or

  2025-04-16

  

  The canonical HotStart™ 2X Green qPCR Master Mix to which α2, α3, or α5 contribute are highly similar. Therefore, differences in ligand affinity will not be large even if a ligand makes optimal use of the small differences in the pockets. As a possible alternative approach to achieve separation of c

• br Materials and methods br Results br Discussion Because

  2025-04-15

  

  Materials and methods Results Discussion Because the Ser/Thr kinase domain of LRRK2 is homologous to that of other MLK family proteins belonging to the MAP3K superfamily, LRRK2 is suggested to be involved in MAPK signaling and activation of neuronal cell death by phosphorylating its downstr

• br Leptin Adiponectin a permissive imbalance Leptin

  2025-04-14

  

  Leptin/Adiponectin: a permissive imbalance Leptin, a satiety hormone, is encoded by the obesity (ob) gene. It essentially functions as an energy sensor which is involved in the regulation of body weight by sending signals to the Sulfo-NHS-Biotin to reduce appetite (Woods and D'Alessio, 2008). Ob

• br Introduction Rhamdia quelen jundi Silurifomes Heptapterid

  2025-04-14

  

  Introduction Rhamdia quelen (jundiá, Silurifomes, Heptapteridae) is a neotropical catfish widely distributed in Central and South America (Silfvergrip, 1996). This species shows high potential for the aquaculture industry, due to an elevated growth rate, good carcass yield, and easy reproduction

• Aprotinin br Conflicts of interest br Introduction Photodyna

  2025-04-11

  

  Conflicts of interest Introduction Photodynamic Therapy (PDT) is a technique used for the treatment of several malignant and non malignant diseases (Akimoto, 2016, Keyal, Bhatta, Wang, 2016, Morton, Szeimies, Sidoroff, Wennberg, Basset-Seguin, Calzavara-Pinton, Gilaberte, Hofbauer, Hunger, Kar

• br Acknowledgment This study was supported by Japan Society

  2025-04-11

  

  Acknowledgment This study was supported by Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [grant number 15K15031]. Introduction Glioma is the leading malignancy of astrocyte origin in the brain. The most aggressive, invasive, and destructive glioma

• Atherosclerosis is a chronic lipid metabolism disorder linke

  2025-04-11

  

  Atherosclerosis is a chronic lipid metabolism disorder linked with lipid accumulation within the arterial wall and subsequent formation of foam cells and vascular disease [96], [97]. The level of apelin is decreased in human atherosclerotic coronary arteries [4], and coronary collateral formation in

• br Conclusion We present here the first

  2025-04-10

  

  Conclusion We present here the first comprehensive analysis of B-Raf-induced transcriptional activation in insulinoma cells. The B-Raf-induced signaling cascade targets the c-Fos and the c-Jun genes. Both gene products are constituents of the AP-1 transcription factor. The phosphatases MKP-1 and

• br Materials and methods br Results In order to eval

  2025-04-09

  

  Materials and methods Results In order to evaluate changes in the amount of PKC-θ expressed by MEL cells at different stages of the cell cycle, we measured the level of the kinase in cells collected from cultures containing 90% of cells in the interphase or 80% cells synchronized at the metaph

• There are increasing repeated reports of amphotericin B

  2025-04-07

  

  There are increasing repeated reports of amphotericin B-resistance in pathogenic fungi including Candida spp. [35], [36]. Nolte et al. characterized some fluconazole and amphotericin B-resistant Candida albicans isolates from leukemia patients [37]. Fan-Havard et al. (1991) have shown multi-antifung

• br Antifungal resistance what is in a name Antifungal resist

  2025-04-07

  

  Antifungal resistance, what is in a name? Antifungal resistance is an emerging and hot topic in the field of medical mycology. Microbiological resistance is identified by determining minimal inhibitory concentrations (MICs) in vitro for a given antifungal and interpreting this value according to

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