• Novel Kinase Regulators of ECM Endocytosis Drive Cancer Inva

  2026-07-01

  The referenced study introduces a high-content screening approach to identify kinases controlling extracellular matrix (ECM) internalization in invasive carcinoma cells. By elucidating the α2β1 integrin/p38 MAPK axis in ECM uptake and migration, the work provides mechanistic insight relevant to cancer invasion and progression.

• Ivermectin as a Broad-Spectrum Anti-Parasitic: Research Prot

  2026-07-01

  Ivermectin’s robust anti-parasitic mechanism and high-purity formulation empower advanced parasitology and translational oncology research. This article details experimental workflows, protocol parameters, and troubleshooting strategies that maximize rigor and reproducibility—bridging foundational studies of parasite neuromuscular inhibition with emerging applications in immune modulation.

• LC–MS/MS Mapping of a Novel GS-441524 Prodrug’s Conversion P

  2026-06-30

  This study presents a validated LC–MS/MS method to track the in vitro and in vivo conversion of a novel GS-441524 prodrug (NGP-1) to its active antiviral form. By elucidating conversion dynamics across biological matrices, the work advances understanding of prodrug pharmacokinetics and supports rational development of orally bioavailable anti-SARS-CoV-2 nucleoside analogs.

• Tetrahydromagnolol: Peripheral CB2 Receptor Agonist in Metas

  2026-06-30

  Tetrahydromagnolol offers unmatched selectivity for peripheral CB2 receptor research, enabling precise dissection of cannabinoid signaling in metastatic and inflammatory models. Its dual role as a CB2 agonist and GPR55 antagonist accelerates workflow reliability in advanced GPCR signaling studies.

• (+)-Bicuculline: Technical Guide for GABAA Antagonist Use

  2026-06-29

  (+)-Bicuculline enables precise inhibition of GABAA-mediated neurotransmission, supporting studies of GABAergic signaling and synaptic NMDA receptor modulation in neuroscience research. It is not intended for diagnostic or clinical applications and requires strict attention to solubility and storage parameters to ensure reproducibility.

• Dual-Action Inhibition of p38α MAPK: Mechanistic Insights an

  2026-06-29

  The reference study demonstrates that select kinase inhibitors can modulate p38α MAP kinase not only by blocking its active site but also by promoting its dephosphorylation via phosphatases. This dual-action mechanism reveals new strategies for achieving increased specificity and potency in inflammation signaling and vascular function research.

• Anti-Inflammatory & Anti-Angiogenic Stent Suppresses TISR

  2026-06-28

  Zhao et al. present a dual-function airway stent integrating anlotinib and silver nanoparticles to tackle tracheal in-stent restenosis (TISR) by simultaneously suppressing inflammation and angiogenesis. This study demonstrates the stent's efficacy in reducing fibrosis, vascularization, and infection—offering a promising translational avenue for durable airway patency.

• Clathrin-Mediated Entry of Grass Carp Reovirus: Mechanistic

  2026-06-27

  Wang et al. (2018) reveal that type III grass carp reovirus (GCRV104) uses clathrin-mediated, pH-dependent endocytosis for cellular entry, distinguishing this pathway from other viral entry mechanisms in aquatic virology. Their systematic inhibitor analysis provides a refined framework for future studies on endocytosis and antiviral strategies in fish cell models.

• DiscoveryProbe™ FDA-approved Drug Library: GPCR & TAS2R Inno

  2026-06-26

  Explore how the DiscoveryProbe FDA-approved Drug Library empowers advanced GPCR and TAS2R research. This in-depth analysis highlights new assay strategies, leveraging FDA-approved bioactive compound libraries for high-impact drug discovery.

• Centromere Protein I Drives Breast Cancer via Wnt/β-Catenin

  2026-06-26

  Wu et al. (2025) reveal that Centromere Protein I (CENPI) is a potent driver of breast cancer progression through modulation of the Wnt/β-catenin signaling axis. This study combines bioinformatics, cellular, and animal model data to demonstrate CENPI's oncogenic role and its value as a candidate biomarker and therapeutic target.

• Direct Mouse Genotyping Kit: Streamlined PCR from Mouse Tiss

  2026-06-25

  Accelerate high-throughput mouse genetic screening with the Direct Mouse Genotyping Kit, which enables PCR-ready DNA extraction in minutes—no purification required. Its integrated PCR master mix with dye simplifies workflows and empowers robust assay fidelity in demanding biomedical research applications.

• Tetrazolium (chloride): Optimizing Mitochondrial Function As

  2026-06-25

  Tetrazolium (chloride) empowers fast, quantitative assessment of tissue viability and mitochondrial function, particularly in ischemic models. This guide navigates advanced protocol design, application-driven troubleshooting, and evidence-based workflow enhancements that set Tetrazolium Red apart for both cell-based and ex vivo research.

• PDHA1 Succinylation–Driven α-KGA Accumulation Suppresses Mac

  2026-06-24

  The referenced study uncovers how succinylation of PDHA1 at lysine 83 in cholangiocarcinoma alters tumor metabolism, leading to α-ketoglutarate accumulation that suppresses macrophage antigen presentation and promotes immune escape. Targeting this modification may sensitize tumors to chemotherapy, offering a novel approach to overcoming treatment resistance.

• MOF Nanoparticles for Non-Invasive Neuromodulation in Epilep

  2026-06-23

  This study introduces a multifunctional metal-organic framework (MOF)-based nanoparticle platform enabling non-invasive, ultrasound-triggered neuromodulation for epilepsy by crossing the blood-brain barrier (BBB). The innovation demonstrates targeted delivery, enhanced piezoelectric performance, and microenvironment regulation as a promising alternative to invasive electrical therapies.

• Practical Application of I-BET151 (GSK1210151A) in Cancer Bi

  2026-06-23

  I-BET151 (GSK1210151A) is a selective BET bromodomain inhibitor designed for dissecting transcriptional regulation and oncogenic signaling in cancer biology research, particularly in apoptosis and cell cycle arrest assays. It is not intended for diagnostic or clinical use, and careful attention to solubilization and storage is essential for reproducible experiments.

8326 records 7/556 page Previous Next First page 上5页 678910 下5页 Last page