• LGK-974: Targeted PORCN Inhibition for Advanced Wnt Pathw...

  2026-01-14

  Explore the scientific foundation and translational potential of LGK-974, a potent and specific PORCN inhibitor, as a next-generation tool for Wnt-driven cancer therapy. This article uniquely dissects LGK-974's mechanism, benchmarks it against evolving strategies, and highlights its role in overcoming resistance in pancreatic cancer models.

• I-BET151: Selective BET Inhibitor for Cancer Biology & Ep...

  2026-01-14

  I-BET151 (GSK1210151A) is a benchmark selective BET bromodomain inhibitor empowering cancer biology research with robust, reproducible modulation of epigenetic pathways. Discover stepwise protocols, cutting-edge use-cases in apoptosis and cell cycle arrest assays, and troubleshooting strategies for maximizing experimental outcomes in models from MLL-fusion leukemia to super-enhancer-driven tumors.

• Scenario-Driven Best Practices for DiscoveryProbe™ FDA-ap...

  2026-01-13

  This article delivers a scenario-based, evidence-backed guide for deploying the DiscoveryProbe™ FDA-approved Drug Library (SKU L1021) in high-throughput and high-content cell viability, proliferation, and cytotoxicity assays. Drawing on real laboratory challenges, recent literature, and comparative analysis, it showcases how this library accelerates drug repositioning, enhances pharmacological target identification, and ensures robust workflow reproducibility for biomedical researchers.

• Unraveling Cell Death Pathways at Single-Cell Resolution:...

  2026-01-13

  Explore how mechanistic insight into cell viability and death—enabled by the AO/PI Double Staining Kit—empowers translational researchers to dissect apoptosis and necrosis in complex disease models. This thought-leadership article connects the latest advances in single-cell technologies, highlights experimental best practices, and maps the strategic value of dual fluorescent cell staining for next-generation cancer and virology research.

• 3-Aminobenzamide (PARP-IN-1): Reliable Solutions for PARP...

  2026-01-12

  This article provides an evidence-based, scenario-driven guide for biomedical researchers evaluating 3-Aminobenzamide (PARP-IN-1) (SKU A4161) in cell viability, cytotoxicity, and disease modeling workflows. Drawing on recent literature and practical lab challenges, it details how this potent PARP inhibitor from APExBIO supports reproducible, sensitive assays and addresses common pitfalls in experimental design.

• DiscoveryProbe™ FDA-approved Drug Library: Scenario-Drive...

  2026-01-12

  Gain actionable insights into addressing real-world challenges in cell viability and high-content screening assays using the DiscoveryProbe™ FDA-approved Drug Library (SKU L1021). This scenario-driven guide synthesizes best practices, protocol optimization, and library management—grounded in peer-reviewed data—to help researchers achieve reproducible and robust drug screening results.

• LGK-974: Next-Generation PORCN Inhibitor for Precision Wn...

  2026-01-11

  Discover how LGK-974, a potent and specific PORCN inhibitor, revolutionizes Wnt signaling pathway inhibition for advanced cancer research. Explore its unique mechanism, applications in Wnt-driven models, and its potential for targeting pancreatic cancer with RNF43 mutation and HNSCC.

• AO/PI Double Staining Kit: Precision Fluorescent Cell Via...

  2026-01-10

  The AO/PI Double Staining Kit (SKU K2238) enables rapid and reliable cell viability, apoptosis, and necrosis detection using Acridine Orange and Propidium Iodide dual staining. This kit offers clear discrimination among viable, apoptotic, and necrotic cells for fluorescence microscopy and flow cytometry. Its robust, validated protocol supports high-quality results for cell biology, cancer research, and cytotoxicity testing.

• Oligo (dT) 25 Beads: Streamlined Magnetic Bead-Based mRNA...

  2026-01-09

  Oligo (dT) 25 Beads from APExBIO deliver unparalleled efficiency and selectivity for eukaryotic mRNA isolation, leveraging polyA tail capture for rapid, high-purity results. This guide details optimized workflows, advanced applications—such as next-generation sequencing sample preparation—and troubleshooting strategies to maximize your magnetic bead-based mRNA purification success.

• Rucaparib (AG-014699, PF-01367338): Reliable PARP1 Inhibi...

  2026-01-09

  This article guides biomedical researchers through practical, scenario-driven challenges when using PARP inhibitors in cell viability and DNA damage response assays. Highlighting 'Rucaparib (AG-014699, PF-01367338)' (SKU A4156), we deliver evidence-based strategies for experimental reproducibility, protocol optimization, and product selection, ensuring robust results and workflow efficiency.

• Acifran: Selective HM74A/GPR109A Agonist for Lipid Metabo...

  2026-01-08

  Acifran is a high-purity, selective agonist for HM74A/GPR109A and GPR109B, enabling precise modulation of lipid signaling pathways in metabolic disorder research. Structural and biochemical studies validate its specificity and mechanism of action. Its robust profile makes Acifran a preferred tool for dissecting G-protein coupled receptor function.

• DiscoveryProbe FDA-approved Drug Library: Elevating High-...

  2026-01-07

  The DiscoveryProbe™ FDA-approved Drug Library empowers rapid, translational research with 2,320 clinically validated compounds in ready-to-screen formats. Its robust design accelerates drug repositioning, pharmacological target identification, and signal pathway analysis—enabling breakthroughs in oncology, neurodegeneration, and beyond.

• Scenario-Driven Solutions with AO/PI Double Staining Kit ...

  2026-01-06

  This article delivers a scenario-based, evidence-oriented exploration of the AO/PI Double Staining Kit (SKU K2238), highlighting how it resolves common laboratory challenges in cell viability, apoptosis, and necrosis assays. Integrating real-world questions, quantitative data, and peer-reviewed references, it guides biomedical researchers, technicians, and postgraduate scientists in optimizing fluorescent cell staining workflows for reproducibility and interpretability.

• Redefining Cell Fate Decisions: Mechanistic and Strategic...

  2026-01-05

  As cell death pathway analysis becomes increasingly central to translational research, the AO/PI Double Staining Kit from APExBIO offers a mechanistically rigorous and strategically flexible solution for distinguishing viable, apoptotic, and necrotic cells. This thought-leadership article explores the mechanistic underpinnings of Acridine Orange and Propidium Iodide staining, synthesizes recent evidence—including findings from combined mTOR and autophagy inhibitor studies in melanoma—and provides actionable guidance for integrating advanced cell viability assays into translational workflows. By contextualizing the AO/PI Double Staining Kit within the evolving landscape of cancer research and drug discovery, the article empowers researchers to unlock new frontiers in cell health analytics.

• AO/PI Double Staining Kit: Precision Cell Viability and A...

  2026-01-04

  The AO/PI Double Staining Kit enables rapid, reliable cell viability and apoptosis detection using Acridine Orange and Propidium Iodide staining. This fluorescence-based cell viability assay distinguishes viable, apoptotic, and necrotic cells with high specificity. APExBIO’s K2238 kit is a validated tool for cancer research and advanced cell death pathway analysis.

15967 records 1/1065 page Next 12345 下5页 Last page