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In large biopsies series from ALK NSCLC treated patients
2023-11-30
In large biopsies series from ALK+ NSCLC treated patients, the number of detected mutations increased after second generation ALKi (Gainor et al., 2016) and in one study were present in 56% of the entire cohort (Shaw et al., 2013b). For example, the rate of G1202R mutations increases from 2% in post
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Sphingolipids such as ceramides and glucosylceramides are an
2023-11-30
Sphingolipids, such as ceramides and glucosylceramides, are an important class of bioactive lipids. The levels of these lipids change as a function of adipose tissue mass and functionality, and are partially driven by cellular availability of palmitoyl-CoA. Aberrant accumulation of ceramide, glucosy
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Ramipril The biology of the A BR is complex and needs
2023-11-30
The biology of the A2BR is complex and needs to be considered contextually as the expression and effect of receptor engagement varies according to time post hypoxic injury, cell type and downstream signaling pathway. For example, A2BR expression is dynamic - low under basal and increasing under isch
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Similar to V the temporal
2023-11-30
Similar to V1, the temporal neocortex of mammals, including the primary auditory cortex (A1), is densely innervated by 5-HT fibers originating mainly in the dorsal raphe nucleus (Campbell et al., 1987, Harding and Paxinos, 2004, Törk, 1990), and the major AM251 of 5-HTRs are expressed throughout th
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Prostate cancer is the second
2023-11-30
Prostate cancer is the second leading cause of cancer-related death in men in the United States [25]. Similar to pancreatic cancer, prostate cancer has few diagnostic options available, particularly to differentiate indolent from aggressive disease. Axl is also overexpressed in ∼50% of prostate canc
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Polyphenols like flavonoids have the potential to penetrate
2023-11-30
Polyphenols like flavonoids have the potential to penetrate into lipid bilayers which is vital for enabling protection against oxidation. Rosmarinic cx 5461 is a natural polyphenol antioxidant isolated from Sphaeranthus amaranthoides. Polyphenols can inhibit the propagation of lipid oxidation by tw
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exemplifies three of the compounds investigated in the selec
2023-11-30
exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC The GKT137831 australia as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradat
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Earlier studies showed that exposure of cells to IR caused
2023-11-30
Earlier studies showed that exposure of cells to IR caused ATM-dependent phosphorylation of 53BP1, as judged by electrophoretic mobility shift [24], [25], [26]. To date, the only known in vivo 53BP1 phosphorylation site(s) are Ser25 and possibly Ser29 [27]. In the course of our studies, we noticed t
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Recently competitive inhibitors of arginase have been develo
2023-11-30
Recently, competitive inhibitors of arginase have been developed which have greater specificity for the enzyme. Initial development of these compounds involved determination of the crystal structure of arginase. Christianson and colleagues found that a binuclear manganese cluster was required for ca
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Limitations of this study include the
2023-11-30
Limitations of this study include the use of HL-1 cardiomyocytes, which show different characteristics than primary cardiomyocytes [56]. Furthermore, sustained TAC in Ampkα1-deficient mice did not favorably influence cardiac function [33]. It must be kept in mind that global Ampkα1-deficiency may af
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br Conclusion br Introduction Breast cancer
2023-11-30
Conclusion Introduction Breast cancer is the most common cancer and second leading cause of cancer-related deaths in women [1,2]. There were about 1.7 million new cases of breast cancer worldwide in 2012 [3], and the number of new cases of female breast cancer is expected to increase to 3.2 mi
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PF-573228 br Materials and method br Results
2023-11-29
Materials and method Results and discussion Conclusion The adsorption behaviors of 5 antibiotics on 5 types of microplastic particles were investigated using batch type experiments. Our results showed that adsorption capacities varied among antibiotics, plastic types, and environmental cond
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Infections inflammation and corneal transplant can all cause
2023-11-29
Infections, inflammation, and corneal transplant can all cause corneal neovascularization via upregulation of inflammatory cytokines, which attract myeloid find more information into the cornea. These myeloid cells establish a cycle of cytokine secretion and further myeloid cell recruitment in the
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Modulating the ability of tumor cells to detoxify ROS is
2023-11-29
Modulating the ability of tumor Rifapentine australia to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and tu
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br Conclusions br Acknowledgments The
2023-11-29
Conclusions Acknowledgments The authors are thankful to Hugo Santos, Olga Martinez and Ricardo Lacerda for the technical assistance provided in the maintenance of the aquaria. This work was supported by national funds, through FCT and co-funded by the European Regional Development Fund (ERDF)
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