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cyclin dependent kinases Several studies have found decrease
2021-09-23
Several studies have found decreased astroglial and neuronal cell numbers and cyclin dependent kinases damage after OP exposure. Neuronal loss and brain lesions increase proportionally to the severity and duration of OP-induced seizures (Albuquerque et al., 2006, Carpentier et al., 2000, Gullapalli
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br Acknowledgements This work was supported by the
2021-09-23
Acknowledgements This work was supported by the grants from National key Basic Research Program of China (2012CB124702), 948 Program (2015-Z33), National Natural Science Foundation of China (31172093, 31301947), the National Science Foundation for Fostering Talents in Basic Research (J1103510), S
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It is increasingly argued that the immunosuppressive
2021-09-23
It is increasingly argued that the immunosuppressive effects of GCs are conferred indirectly by GR through the activation of genes encoding proteins that inhibit HS-173 australia of proinflammatory genes 86, 87, 88. Genomic studies offer another mechanism compatible with the idea that GC-mediated r
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Type diabetes mellitus is characterised by
2021-09-23
Type 2 diabetes mellitus is characterised by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic beta KU-0059436 [1]. The condition occurs when the pancreatic beta cells are unable to compensate for increased insulin demand due to insulin resistance in pe
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Whereas accurate measurement of glucagon in humans has been
2021-09-23
Whereas accurate measurement of glucagon in humans has been possible since the early 1950s proper measurements in rodents, have not. That said, plasma concentrations of glucagon have been reported in rodent studies [21] using C-terminal specific methods but what has been lacking is the secretory dyn
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TAK-285 Fig a and b illustrates a slow inhibition
2021-09-23
Fig. 3a and b illustrates a slow inhibition by PMA in 2 μM Ca2+. Moreover, channel inhibition was reversed by addition of PKC19–31, a peptide inhibitor specific for PKC, as shown in Fig. 3c. In three experiments, Im was reduced to 14.5±0.6% of the control value by PMA to increase to 207.6±73.6% by a
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br Conclusion In the present study we found that the
2021-09-23
Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used
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br Introduction As a fundamental
2021-09-23
Introduction As a fundamental metal-dependent hydrolytic enzyme, inorganic pyrophosphatase (PPase) exhibits a specific catalytic ability, in which one molecule of inorganic pyrophosphate (PPi) can be transformed into two orthophosphate (Pi) ions [1,2]. The process of transformation is extremely e
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br Materials and methods br Results br Discussion It is
2021-09-22
Materials and methods Results Discussion It is known that MAPKs and Akt signaling can regulate cell migration [[24], [25], [26]]. In this study we found that dTAT-WKYMVm stimulates ERK, p38 and Akt phosphorylation in naïve CD4 T cell (Fig. 3A). However their activation did not affect naïve
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The presence of FBP in nuclei seems
2021-09-22
The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas
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The second patient had a homozygous substitution within exon
2021-09-22
The second patient had a homozygous substitution within exon 6 (c.538C>T). The parents were heterozygous and showed no clinical or immunological defect. The mutation has been predicted to alter a potential exonic splicing enhancer (ESE) site. Therefore, exon 6 skipping could be explained by the ESE-
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Hyperhomocysteinemia HHcy is a clinical condition characteri
2021-09-22
Hyperhomocysteinemia (HHcy) is a clinical condition characterized by increased levels of plasma homocysteine (Hcy) and a well-known risk factor for CVDs. Hcy is a sulfur-containing non-protein amino more hints formed during the intracellular conversion of methionine to cysteine. Previous study demo
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Anti apoptotic Bcl proteins have
2021-09-22
Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients w
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HCV is a highly diverse virus with
2021-09-22
HCV is a highly diverse virus with seven known genotypes (GT1–7) and multiple subtypes (Gower et al., 2014, Messina et al., 2015, Smith et al., 2014). Patients infected with HCV develop a heterogeneous population of viral species known as quasispecies due to low fidelity of the RNA-dependent RNA pol
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cholecystokinin receptor br Discussion Using HBV transgenic
2021-09-22
Discussion Using HBV transgenic mice, Kim, et al. first reported that the HBx gene caused HCC [34]. Since then, transgenic mice have become a useful experimental model for defining the molecular events of HBV hepatitis, and HBV-related hepatocarcinogenesis. In the present study, we first confirme
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