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The schematic diagram of the antagonistic
2021-10-15
The schematic diagram of the antagonistic interactions of Zn2+ and neurosteroids (NSs) at GABA-A receptors is summarized in Fig. 7. Neurosteroids exhibit powerful seizure protective effects against experimental seizures probably through the potentiation of synaptic and extrasynaptic GABA-A receptor-
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Focal adhesion kinase Fakir et al also known
2021-10-15
Focal adhesion kinase (Fakir et al., 2006), also known as non-receptor tyrosine kinase (PTK2), is a 125-kDa protein that regulates cell migration, adhesion, proliferation, and survival (Tavora et al., 2014; Yang et al., 2016; Tian et al., 2017). Many studies have observed FAK overexpression and/or h
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Another important question for future studies will be whethe
2021-10-15
Another important question for future studies will be whether FAAH inhibitors work to normalize impairments in fear extinction that are known to be produced by environmental insults such as exposure to abused drugs and stress 97, 103. Indeed, several authors have posited utility of FAAH inhibitors f
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Ghrelin (rat) In the present study LLY
2021-10-15
In the present study, LLY-507 suppressed the proliferation of HGSOC Ghrelin (rat) via induction of apoptosis. Moreover, the colony-formation assay showed the long-term effects of SMYD2 inhibitors on HGSOC. It has been reported that LLY-507 induces an anti-tumor effect in several types of cancers in
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SETDB is ubiquitously expressed in mouse tissues and more th
2021-10-15
SETDB1 is ubiquitously expressed in mouse tissues, and more than 900,000 ERVs are dispersed through the mouse genome. Nevertheless, the repertoire of ERVs under the control of SETDB1 was limited and highly cell-type specific. Only 17,349 ERVs were associated with H3K9me3 domains in Th2 cells. The va
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It was reported that GPR is
2021-10-15
It was reported that GPR120 is expressed on macrophages in adipose tissue (Oh et al., 2010). Whether GPR120-positive RO4929097 synthesis in human and rat pancreas belongs to macrophages was studied. CD68 is a transmembrane glycoprotein that is highly expressed by human monocytes and tissue macropha
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br Material and methods br Results Consistent with our
2021-10-15
Material and methods Results Consistent with our previous study, SR-SIM and confocal microscopy showed a large number of IBA1-expressing 4716 in all parts of the human cochleae (Fig. 1). IBA1, the microglial and macrophage-specific calcium-binding protein, is involved in the membrane ruffling
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br Experimental br Acknowledgment This work was supported in
2021-10-15
Experimental Acknowledgment This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Glyoxalase I (GLO1) is a zinc enzyme that catalyzes the isomerization of a hemithioacetal, formed from glut
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br Treatment KD is currently the
2021-10-15
Treatment KD is currently the treatment of choice for GLUT1-DS. It is a high-fat, carbohydrate-restricted diet that mimics the metabolic state of fasting; so, the KD relies an exogenous rather than body fat for ketone production, thus maintaining ketosis without weight loss. As the developing br
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br Results br Discussion Postsynaptic trafficking of AMPA re
2021-10-15
Results Discussion Postsynaptic trafficking of AMPA receptors, a process responsible for maintaining the steady-state level of AMPA receptor synaptic transmission, is believed to also actively partake in glutamatergic synaptic plasticity in principal neurons, such the hippocampal CA1 cells. He
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br Results br Discussion Postsynaptic trafficking of AMPA re
2021-10-15
Results Discussion Postsynaptic trafficking of AMPA receptors, a process responsible for maintaining the steady-state level of AMPA receptor synaptic transmission, is believed to also actively partake in glutamatergic synaptic plasticity in principal neurons, such the hippocampal CA1 cells. He
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MRcKO mice showed a comparable degree
2021-10-15
MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G
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br Prospects The prospects for GABAergic
2021-10-14
Prospects The prospects for GABAergic EGTA can be projected from the rate at which new compounds have been introduced (Fig. 1) and the amounts used. More than three billion pounds of NCA-IA insecticides were used in the past seven decades. There was no target site cross-resistance of the NCA-IA
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To date increasing evidence has demonstrated that dysregulat
2021-10-14
To date, increasing evidence has demonstrated that dysregulated lncRNAs are closely associated with the tumorigenesis and development of HCC via ceRNA modes [29,30]. LncRNAs could bind with special miRNAs and abrogate the inhibitory effect of these miRNAs on their targeted transcripts. For example,
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br Conclusions Symptoms from bilateral
2021-10-14
Conclusions Symptoms from bilateral thalamic edema caused by increased venous hypertension can be reversed with appropriate management of the inciting vascular lesion. This case demonstrates a rare patient with decreased CBF in the thalamus in SPECT and completely recovered after factor Xa inhibi
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