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br Role of dynamin in NPRA endocytosis
2021-10-29
Role of dynamin in NPRA endocytosis In recent studies using 125I-ANP binding assay and confocal microscopy, we have examined the role of dynamin in the internalization and trafficking of NPRA in a stably transfected HEK-293 ritodrine [69]. Our findings indicated that ANP treatment of high-densit
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Introduction Glycogen synthase kinase GSK is an
2021-10-29
Introduction Glycogen synthase kinase-3 (GSK-3) is an enzyme playing multiple roles in animal tissues and organs, and (R)-baclofen synthesis is not an exception. Apart from involvement in regulation of apoptosis and survival GSK-3 influences neuronal morphology, synapse formation, memory reconsoli
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Imiquimod hydrochloride The timing and growth of follicles
2021-10-29
The timing and growth of follicles relative to follicle deviation was assessed in 49 cows (Fig. 4) that had NFWE following treatment onset and that had not already established dominance. Because day of deviation did not differ due to treatment, day of estrous cycle, or replicate, data are presented
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br NMDA receptor LBDs The study of GluA was later
2021-10-29
NMDA receptor LBDs The study of GluA2 was later expanded to include NMDA receptors [22]. NMDA receptors are obligate heterotetramers that are composed of two glutamate-binding subunits and two glycine-, or d-serine-, binding subunits. In this study, crystal structures of the NMDA receptor glycine
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It is widely acknowledged that CpG methylation of
2021-10-29
It is widely acknowledged that CpG methylation of the promoter regions of some genes plays an important regulatory role in transcriptional regulation and in the establishment and maintenance of cell type-specific gene expression (Li, 2002, Jaenisch and Bird, 2003). This study obtained multiple lines
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Somatostatin analogues are among the first
2021-10-29
Somatostatin analogues are among the first peptide-based drugs used in cancer imaging and therapy (for review see Reubi, 2003). Treatment of tumors by the use of peptide analogues labeled with cytotoxic agents acting via specific receptors is also under investigation for neuropeptide Y (Koglin and B
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Of note the intracellular egg
2021-10-29
Of note, the intracellular egg compartment exhibiting SA-β-gal activity also exhibits lipofuscin auto-fluorescence (Fig. 6B), and it is co-stained with the lipid-specific dye SBB (Supplemental Fig. 5). On the one hand, these findings reflect the fact that the pool of yolk protein contains lipoprotei
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Similarly spectrophotometric titrations were carried out und
2021-10-29
Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant 8-CPT-2Me-cAMP, sodium salt band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochromic effect along with a bat
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LPCs have been previously described as potential anti diabet
2021-10-29
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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br Introduction The nature of chemotherapies is to relieve
2021-10-29
Introduction The nature of chemotherapies is to relieve the tumor burden of the patients by eliminating cancer fty720 via inducing cell death, mostly regulated cell death represented by apoptosis [1,2]. Dozens of anticancer agents including clinically used ones kill cancer cells by promoting apop
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To date increasing evidence has demonstrated that
2021-10-29
To date, increasing evidence has demonstrated that dysregulated lncRNAs are closely associated with the tumorigenesis and development of HCC via ceRNA modes [29,30]. LncRNAs could bind with special miRNAs and abrogate the inhibitory effect of these miRNAs on their targeted transcripts. For example,
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The site of metastasis in breast cancer
2021-10-29
The site of metastasis in breast cancer often contributes to the patient’s OS. Patients with bone metastasis from their breast cancer often have a notably increased survival over patients with visceral or 623 synthesis metastasis. In this analysis, ER+/HER2+ patients were noted to have a higher rat
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We have confirmed that HO suppressed TLR MyD
2021-10-28
We have confirmed that HO-2 suppressed TLR4/MyD88-dependent signaling by down-regulating the downstream factors (TNF-α and IL-6) in mouse cerebral vascular endothelial cells [13]. In this study, HO-2 overexpression mouse model was generated and to investigated the role of HO-2 in macrophage inflamma
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br Author contributions br Conflict of interest br
2021-10-28
Author contributions Conflict of interest Acknowledgments We appreciate technical support of the Research Support Center at the Graduate School of Medical Sciences of the Kyushu University. This study was supported by the Uehara Memorial Foundation and a KAKENHI grant from the Ministry of E
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To apply the recently developed
2021-10-28
To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the KN-93 Phosphate and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this end
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