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Sequences of HKI and HKII from humans were
2021-11-19
Sequences of HKI and HKII from humans were compared to those of the Atlantic salmon to better understand the observation of HKI movement to the mitochondrial fraction in this study, as HKI in mammals is commonly assumed to be mostly passively regulated by product inhibition, with little evidence of
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The Hedgehog signaling pathway HH pathway hereafter
2021-11-19
The Hedgehog signaling pathway (HH pathway hereafter) is vital for development and tissue homeostasis. [4] In recent years, studying the role of the HH pathway in carcinogenesis and cancer stemness has highlighted the HH inhibitors as putative cancer therapeutics [5]. However, clinical application o
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AP and NF B activation is inhibited by curcumin
2021-11-19
AP-1 [16], [17] and NF-κB activation is inhibited by curcumin (diferuloylmethane) [18], [19], the yellow component of Curcuma longa that gives curry its colour and flavour. Curcumin has shown anti-inflammatory and antioxidant properties [20], [21], [22], [23], [24], [25], [26] due to the inhibition
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This variant has also been related
2021-11-19
This variant has also been related to a better treatment response in patients with metastatic colorectal cancer subjected to irinotecan-based chemotherapy (Kweekel et al., 2008). Inheritance of this metabolic variability has also been stated to influence better treatment outcomes in breast cancer pa
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Given the involvement of dysregulated S nitrosylation in mul
2021-11-19
Given the involvement of dysregulated S-nitrosylation in multiple pathological conditions, a number of approaches to regulate S-nitrosylation therapeutically are being tried in multiple indications [18]. In the lung, GSNO releasing compounds and GSNOR inhibitors are being considered as potential the
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Finally LC ESI MS MS
2021-11-19
Finally, LC-ESI-MS/MS was applied to explore the effects of increased fT4 levels 4 and 8 weeks after induced thyrotoxicosis and have revealed an upregulation of proteins involved in blood coagulation, thus providing a clear association [126]. Conclusions Introduction Diabetes mellitus (DM) ha
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As discussed above both endogenous and exogenous lesions
2021-11-19
As discussed above, both endogenous and exogenous lesions can lead to adverse health effects [43]. Damaged nucleobases can block DNA replication which is often lethal to cells [44]. The effectiveness of DNA restoration by DNA glycosylases should be closely monitored to gain an insight of the functio
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We report here a patient with a
2021-11-18
We report here a patient with a one-base frame-shift deletion in the PURA gene that presented an unusual phenotype including persistent hypoglycorrhachia. We propose a possible link between hypoglycorrhachia and PURA dysfunction postulating PURA as a GLUT1 regulator. We therefore hypothesize that mu
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A key limiting factor in the semi
2021-11-18
A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Tylosin tartrate australia of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [3
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br In vivo actions of GLP
2021-11-18
In vivo actions of GLP-1/GLP-1R agonists on the vascular endothelium Using contrast-enhanced ultrasound, male Sprague Dawley rats receiving an intravenous infusion of native GLP-1 (30 pmol/kg/min) for 2 h demonstrated significant improvements in both microvascular blood volume and microvascular b
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In Solloway and colleagues reported that mice
2021-11-18
In 2015, Solloway and colleagues reported that mice with alpha cell hyperplasia due to inactive hepatic glucagon receptor signaling may most likely be caused by amino Alfacalcidol dependent mechanisms [11]. The authors then showed these adaptations are regulated by ‘mechanistic target of rapamycin’
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Galactosidase Gal EC is an enzyme exoglycosidase and the
2021-11-18
α-Galactosidase (α-Gal, EC 3.2.1.22) is an enzyme exoglycosidase, and the main role of this enzyme is the enzymolysis of α-galactoside. After this hydrolysis, galactosylation of cyclodextrins by the α-galactosidase occurs, thus forming α-galactosyl-cyclodextrin. This branched CD is easy to dissolve
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FXR agonists represent an attractive class of drugs
2021-11-18
FXR agonists represent an attractive class of drugs for patients with PFIC. Synthetic and semi-synthetic FXR agonists, with higher affinity and potency to activate FXR, have been successfully tested in animal models of cholestasis. In these murine models, the semi-synthetic steroidal FXR ligand obet
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In recent years it was
2021-11-18
In recent years, it was discovered in animals that certain types of non-apoptotic cell death are strictly dependent on iron and ROS. The term ‘ferroptosis’, derived from the Greek word ‘ptosis’ (falling) and the Latin word ‘ferrum’ (iron), is coined to describe such cell death phenomena. Cytoplasmic
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IFN-alpha 1, human recombinant protein HCC metastasis is a m
2021-11-18
HCC metastasis is a multistep, multifactorial process, including adhesion of tumor IFN-alpha 1, human recombinant protein to the extracellular matrix (ECM), remodeling and degradation of ECM, invasion through local tissue, intravasation into blood or lymph vessels, and forming new tumors at distant
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