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Newly identified evidence has put immune
2021-12-27
Newly identified evidence has put immune checkpoint inhibitors into the spotlight. However, even though they have been reported to achieve optimistic outcomes [67], there is still a provocative question about their limitations [68]. The solid evidence above has provided us with translational values
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In conclusion studies of the regulation of the HO
2021-12-27
In conclusion, studies of the regulation of the HO-1/BVR/CO pathway by selective pharmacological approaches may lead to the discovery of novel compounds for the treatment of diverse diseases. Recent results validate the use of advances in targeting HO-1 in various vascular diseases. However, there a
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adenosine antagonist Recently it has been found that treatme
2021-12-27
Recently, it has been found that treatment of human phagocytic adenosine antagonist or microvascular endothelial cells with NO donors inhibited the O2− generating capacity of NADPH oxidase [[8], [9], [10], [11]], which may involve down-regulation or S‑nitrosylation of the p47phox subunit (a cytosol
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br Material and methods br Results br Discussion In
2021-12-27
Material and methods Results Discussion In this paper, an HCV molecular epidemiological study was conducted in DU sentinel surveillance sites in 20 prefecture-level cities across Guangdong Province, and the different subtype distributions between IDU and NIDU were compared. Owing to the lac
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miRNAs post transcriptionally regulate gene expression by cl
2021-12-27
miRNAs post-transcriptionally regulate gene carnosic acid by cleaving mRNA or inhibiting translation of target gene transcripts. Vita analysis of HBV genome sequence suggested that miR-185-5p may not directly act on HBV mRNAs, which suggested that miR-185-5p might suppress HBV gene expression and r
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In addition to changes in the Rho isoforms all
2021-12-27
In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer AZ20 (Chan et al., 2005, Fr
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bax pathway Introduction GPR is a class A type of G Protein
2021-12-27
Introduction GPR119 is a class A type of G Protein coupled receptor, which is expressed primarily in pancreatic β-cells and the K and L bax pathway of the gastrointestinal tract [1], [2], [3]. Activation of GPR119 promotes secretion of incretins such as glucagon-like peptide-1 (GLP-1) in the intest
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In addition analysis of the functional elements in the GnRH
2021-12-27
In addition, analysis of the functional elements in the GnRH promoter region also identified other transcription factor binding sites, such as those for GATA-1 and Oct-1. However, those sites were not further validated in this study. Nevertheless, it has been reported that transcription factors such
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Acknowledgements br Introduction The neurotransmitter glycin
2021-12-27
Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is
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NSC 74859 Shikonin represents naphtoquinonic compound isolat
2021-12-27
Shikonin represents naphtoquinonic compound isolated from the Chinese plant Lithospermum erythrorhizon[20]. Shikonin treatment inhibits AKT and ERK signaling pathways and induces apoptosis through FOXO transcription factors and mitochondrial pathway [21], [22]. Recent results suggest inhibition of l
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br Materials and methods br Results
2021-12-27
Materials and methods Results Discussion Ajuba was originally identified as an adaptor protein which communicates cell adhesive events with nuclear responses to remodel the epithelium (Langer et al., 2008; Marie et al., 2003). Recently, increasing evidence has shown that Ajuba functions as
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Pyrogallol is an organic gallic acid converting compound tha
2021-12-27
Pyrogallol is an organic gallic acid-converting compound that has three hydroxyl groups and belongs to the phenol family. Gallic Sodium Phenylbutyrate is obtainable from the galls and barks of various trees, and a simple heating procedure can induce the decarboxylation of gallic acid to produce pyr
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br Methods br Results br Discussion Previous work by
2021-12-27
Methods Results Discussion Previous work by the Hirano group investigated the effect of GIP in murine atherosclerotic models and found infusion of GIP (1–42) by osmotic mini-pumps to decrease lesion size after 4 weeks in non-diabetic as well as in diabetic ApoE−/− mice [8], [9]. Mechanistic
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Based on this evidence future research
2021-12-24
Based on this evidence, future research should be directed towards the identification of actual receptor oligomeric states at the analyzed cellular surfaces. The macromolecular organization of these oligomeric receptors might establish informational hubs, which relay ligand/receptor interactions in
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br Conclusion br Conflict of interest br Acknowledgements br
2021-12-24
Conclusion Conflict of interest Acknowledgements Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial c
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