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VMD v Humphrey et al was used to analyze
2019-10-01
VMD v1.9.2 (Humphrey et al., 1996) was used to analyze the MD trajectories, salt bridge interactions and secondary structure information from each frame. Once the model was optimized, the topological diagram and area and volume of protein cavities were analyzed using PDBsum (Laskowski, 2009) and CAS
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When six chemical inhibitors were incubated
2019-10-01
When six chemical inhibitors were incubated with TRB or TRC and human liver microsomal preparation, HLM2, the results showed that ketoconazole (a CYP3A4 inhibitor) was very effective in inhibiting 4β-C hydroxylation of TRB and TR, whereas sulfaphenazole (a CYP2C9 inhibitor) and quinidine (a CYP2D6 i
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Introduction CYP is a superfamily of heme containing monooxy
2019-10-01
Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I Oxonic acid potassium salt and in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the
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The nuclear receptor related protein
2019-10-01
The nuclear receptor related-1 protein, Nurr1 (NR4A2), is a transcription factor that regulates the ODQ of genes critical for the development, maintenance, and survival of dopaminergic neurons (Alavian et al., 2014, Decressac et al., 2013, Dong et al., 2016, Jankovic et al., 2005, Johnson et al., 2
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In addition to glutamatergic inputs the
2019-10-01
In addition to glutamatergic inputs, the RTn integrates cholinergic, serotonergic and noradrenergic synapses of fibers coming from nuclei located in the brainstem (Asanuma, 1992, Morrison and Foote, 1986, Pare et al., 1988) involved in the alternating firing mode and in the frequency changes of reti
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Herein in continuation of our interest in designing new
2019-10-01
Herein, in continuation of our interest in designing new DNA photocleavage agents [18], we report the synthesis, characterization and DNA binding and cleaving properties of a novel compound: trans-N,N-dimethyl-10,11-di(pyridin-4-ium)-10,11-dihydro-9,12-dioxobenzo[e]phenanthrene tetrafluoroborate (1)
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CH5424802 br Materials and methods br Results br Discussion
2019-09-30
Materials and methods Results Discussion Our previous study showed that ERRγ negatively regulates osteoblast differentiation via inhibiting Runx2 transactivity (Jeong et al., 2009). In the present study, we found that ERRγ also induced miR-433 in osteogenic mesenchymal cell lineage C3H10T1/
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O-propargyl-puromycin mass It is believed that emphysema in
2019-09-30
It is believed that emphysema in smokers is mediated by proteases released from inflammatory O-propargyl-puromycin mass that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysem
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Using the juxtarenal PPE the induction of
2019-09-30
Using the juxtarenal PPE, the induction of juxta- and suprarenal aneurysms is described herein (Fig. 3A). The infra-/suprarenal part of the hbr compound name can now be investigated separately, taking into account different embryological backgrounds and varying reactivity to differing stimuli (revie
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There is evidence that the response of CYP
2019-09-30
There is evidence that the response of CYP450 activity to DEX is species-specific. CYP1A and CYP3A expressions were strongly induced by DEX in porcine hepatocytes (Rasmussen et al., 2014) and in rat and human, but not minipig or beagle dog hepatocytes (Lu and Li, 2001). Within fish, there are also s
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We first confirmed LPS induction of markers known
2019-09-30
We first confirmed LPS-induction of markers known to induce NF-κB signaling in Caco2BB cells, as established for numerous other cell types [31]. We initially selected this approach to monitor NF-κB activation instead of directly monitoring p65 as it is technically straightforward and provides both u
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br Conclusion br Acknowledgment The authors would like to th
2019-09-30
Conclusion Acknowledgment The authors would like to thank “Science and Engineering Research Board (SERB) of Department of Science and Technology (DST) Govt. of India” (Grant No.YSS/2015/002017) for funding the project. Introduction Mutations occurring within EGFR exons 18 to 21 are present
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br Materials and methods br Results and
2019-09-30
Materials and methods Results and discussion Conflict of interest Acknowledgments This work was supported by grants from National 973 Project (2015CB755700) and the Doctoral Starting up Foundation of Henan University of Science and Technology (13480033). Introduction Progression thro
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We initially identified four putative Egr binding sites and
2019-09-30
We initially identified four putative Egr1 Ro 5-3335 kinase (−39/−36, −105/−102, −107/−104, and −227/−224) on the DBH proximal promoter. The deletion and mutagenesis experiments indicate that the motif at −227/−224 is required for Egr1-elicited reduction in DBH promoter activity. It remains to be d
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Our study showed that parental morphine exposure
2019-09-30
Our study showed that parental morphine exposure in the adulthood is associated with an increased tendency toward morphine consumption in F1 but not F2 male offspring. Thus, it seems that trans-generational effects of parental morphine consumption disappear in the second generation. In support of ou
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