• These data indicate that in the context of the

  2020-10-02

  

  These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p

• Enzyme mimics belong to a type of rising catalysts which

  2020-09-30

  

  Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a

• br Materials and methods br Results br

  2020-09-30

  

  Materials and methods Results Discussion and conclusion The cardiac hypertrophy model can be established by two methods: drug induction and operation. The drug induction method is simple, while the operation method is closer to the real development of the disease. In this experiment, accord

• Celiac disease occurs in the small intestine due

  2020-09-30

  

  Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they

• A major finding to emerge from this study is a

  2020-09-30

  

  A major finding to emerge from this study is a conserved regulatory scheme deployed by both innate and adaptive lymphocytes, which is coordinated by a cohort of TFs. The scheme functionally compartmentalizes effector BIRB 796 that circulate between blood and peripheral tissues from self-renewing pr

• Programmed cellular death or apoptosis

  2020-09-30

  

  Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s

• GLP signaling mediates important renal functions as suggeste

  2020-09-30

  

  GLP-1 signaling mediates important renal functions [101], as suggested by the expression of both DPP-4 and GLP-1R in the kidney of several species, including humans [102]. However, controversial data exists on the specific expression pattern of these proteins, based on the specificity and sensitivit

• br Conclusion As far as we know

  2020-09-29

  

  Conclusion As far as we know, this work constituted the first use of silver nitrate staining and sequential FISH in V. vinifera. This technique allowed the unequivocal identification of Ag-NORs and corresponding rDNA loci. Besides, silver nitrate staining and sequential FISH may bring new insight

• thymidine phosphorylase inhibitor br Conformational properti

  2020-09-29

  

  Conformational properties of DGKϵ Interaction of DGKϵ with its lipid substrate A major component of the interaction between DGKϵ and lipid bilayers is the insertion of the hydrophobic segment comprising residues 20–42 into the membrane, as discussed above. However, this is not the only interac

• We have reported previously that aminoacrylate

  2020-09-29

  

  We have reported previously that β-aminoacrylate derivatives of the general structure () are inhibitors of DHODH. In particular, tricyclic derivatives and displayed sub-micromolar IC values against DHODH, and in the case of there was a 1000-fold greater potency compared to the human enzyme (DHOD

• Because aspirin and ibuprofen are NSAIDs both cause a variet

  2020-09-29

  

  Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, Z-IETD-FMK and cerebral microbleeds [13]. Moreover, both cause liver damage [10]. Laster [14] reported a patient with pericarditis treated with aspiri

• Substitutions on the benzene ring of the phenyl acetic acid

  2020-09-29

  

  Substitutions on the benzene ring of the phenyl acetic Repaglinide moiety were evaluated to study their effect on DP and CRTH2 selectivity (). Compound has strong affinity for CRTH2, but it only has moderate affinity for DP. Small substitutions such as methoxy () and fluorine () next to the arylox

• Although PGD was initially considered

  2020-09-29

  

  Although PGD was initially considered to elicit its biological actions through a classical PGD receptor (DP1), later findings suggested that several PGD-mediated actions of eosinophils arise via DP2,, which is also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)

• One common method to replace the wet limestone process

  2020-09-29

  

  One common method to replace the wet limestone process is the use of an amine-based solution as an absorbent to capture SO2. However, almost all of the common amine-based absorbents are highly volatile compounds, whose emissions are air pollutants themselves. Therefore, it is desirable to either use

• Due to its several industrial applications

  2020-09-29

  

  Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian WP 1130 (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 2003) an

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