• Omar Farha and coworkers have recently successfully employed

  2021-04-20

  

  Omar Farha and coworkers have recently successfully employed metal-organic frameworks (MOFs) to tackle these limitations while retaining the essential characteristics of an immobilization material. MOFs consist of metal ions, or small clusters thereof, coordinated with organic ligands. MOFs are high

• Among our patients with anti enolase drusen those

  2021-04-20

  

  Among our patients with anti-enolase drusen, those with a relatively short duration from the onset of visual symptoms to the first visit tended to have normal structure of photoreceptors with preserved visual function, despite the presence of drusen-related RPE abnormalities (Cases 1-3 and 8). In co

• It is particularly notable that CYP D appears

  2021-04-20

  

  It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 AR-C155858 in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and between in

• There is evidence that the

  2021-04-20

  

  There is evidence that the response of CYP450 activity to DEX is species-specific. CYP1A and CYP3A expressions were strongly induced by DEX in porcine hepatocytes (Rasmussen et al., 2014) and in rat and human, but not minipig or beagle dog hepatocytes (Lu and Li, 2001). Within fish, there are also s

• The goal of studying RvE in goblet

  2021-04-20

  

  The goal of studying RvE1 in goblet Calcitriol is to determine if it may be used to preserve ocular surface homeostasis and as a treatment of ocular inflammatory diseases. We found that RvE1 increased glycoconjugate secretion after 2 h, not at 4 h. This suggests that RvE1 has a short, but potent, a

• Although DGK is a lipid modulating enzyme the role of

  2021-04-20

  

  Although DGKγ is a lipid-modulating enzyme, the role of DGKγ in integral cell metabolism has not been reported. We found that DGKγ made a difference on cell metabolism profile in HCC cells, which may be caused partially by the downregulation of GLUT1. Glucose is a major source of energy, and decreas

• br Results br Discussion The sequence

  2021-04-20

  

  Results Discussion The sequence homology-based clustering of the human kinome by Manning et al. (2002) has been extremely useful to organize kinases into Methylcobalamin by sequence relationship. Since kinases are such prominent drug targets, we expect that clustering of the kinases by their i

• In present study we measured the methylation and expression

  2021-04-20

  

  In present study, we measured the methylation and emca australia levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is a h

• br Materials and Methods br Results br Discussion Mitochondr

  2021-04-19

  

  Materials and Methods Results Discussion Mitochondrion not only generates energy but also produces ROS under physiological conditions. However, overnutrition causes mitochondrial congestion and elicits excessive ROS generation, leading to insulin resistance (Muoio, 2014, Houstis et al., 200

• The COMT gene maps to

  2021-04-19

  

  The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT

• br Materials and methods br Results Recombinant N terminally

  2021-04-19

  

  Materials and methods Results Recombinant, N-terminally His6-tagged vCPH was purified to near homogeneity via a modification of the reported procedure and its identity confirmed by intact protein mass spectrometry (Supplementary Fig. 1). As reported, vCPH catalysed two hydroxylations of a PAPK

• CD is a key co stimulation surface marker that can

  2021-04-19

  

  CD28 is a key co-stimulation surface marker that can be detected in all peripheral T berbamine in newborns, and the proportion of CD28bearing T cells reduces progressively with age [reviewed by (Fagnoni et al., 1996; Weng et al., 2009)]. Therefore, CD28nullCD8+ T cells are one of the most acknowled

• In contrast to drospirenone dydrogestrone acts

  2021-04-19

  

  In Sulindac to drospirenone dydrogestrone acts rather neutral at the aldosterone-, glucocorticoid- and androgen-receptor [12]. This indicates that the assessment of a ‘net-overall effect’ on the vascular system is very difficult based on the often discussed ‘partial effects’ of the progestogens. Th

• nadph oxidase Similarly to other investigations the present

  2021-04-19

  

  Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer nadph oxidase (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA observed by

• br Materials and methods br

  2021-04-19

  

  Materials and methods Results To investigate the effect of 17βE on cell proliferation in the human renal tubular epithelia, BrdU uptake was measured in HRTEC primary and 3D-HRTEC cultures, allowing determination of the DNA replication rate. Representative microphotographs show BrdU uptake in H

15853 records 673/1057 page Previous Next First page 上5页 671672673674675 下5页 Last page