• br Experimental br Acknowledgment This work was supported in

  2021-10-15

  

  Experimental Acknowledgment This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Glyoxalase I (GLO1) is a zinc enzyme that catalyzes the isomerization of a hemithioacetal, formed from glut

• br Treatment KD is currently the

  2021-10-15

  

  Treatment KD is currently the treatment of choice for GLUT1-DS. It is a high-fat, carbohydrate-restricted diet that mimics the metabolic state of fasting; so, the KD relies an exogenous rather than body fat for ketone production, thus maintaining ketosis without weight loss. As the developing br

• br Results br Discussion Postsynaptic trafficking of AMPA re

  2021-10-15

  

  Results Discussion Postsynaptic trafficking of AMPA receptors, a process responsible for maintaining the steady-state level of AMPA receptor synaptic transmission, is believed to also actively partake in glutamatergic synaptic plasticity in principal neurons, such the hippocampal CA1 cells. He

• br Results br Discussion Postsynaptic trafficking of AMPA re

  2021-10-15

  

  Results Discussion Postsynaptic trafficking of AMPA receptors, a process responsible for maintaining the steady-state level of AMPA receptor synaptic transmission, is believed to also actively partake in glutamatergic synaptic plasticity in principal neurons, such the hippocampal CA1 cells. He

• MRcKO mice showed a comparable degree

  2021-10-15

  

  MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G

• br Prospects The prospects for GABAergic

  2021-10-14

  

  Prospects The prospects for GABAergic EGTA can be projected from the rate at which new compounds have been introduced (Fig. 1) and the amounts used. More than three billion pounds of NCA-IA insecticides were used in the past seven decades. There was no target site cross-resistance of the NCA-IA

• To date increasing evidence has demonstrated that dysregulat

  2021-10-14

  

  To date, increasing evidence has demonstrated that dysregulated lncRNAs are closely associated with the tumorigenesis and development of HCC via ceRNA modes [29,30]. LncRNAs could bind with special miRNAs and abrogate the inhibitory effect of these miRNAs on their targeted transcripts. For example,

• br Conclusions Symptoms from bilateral

  2021-10-14

  

  Conclusions Symptoms from bilateral thalamic edema caused by increased venous hypertension can be reversed with appropriate management of the inciting vascular lesion. This case demonstrates a rare patient with decreased CBF in the thalamus in SPECT and completely recovered after factor Xa inhibi

• Although it is well documented that FAAH

  2021-10-14

  

  Although it is well documented that FAAH substrates can elicit analgesic effects [for review see [47,48] and that systemic poly I:C administration induces mechanical allodynia in rats [14], to our knowledge this is the first study to demonstrate that enhancing FAAH substrate levels can modulate TLR

• We also intended to determine

  2021-10-14

  

  We also intended to determine the possible mechanism underlying EZH2 upregulation in the PC. Although no recurrent mutations of EZH2 have been described in CLL [27, 28, 29], we aimed to rule out the possibility of activating mutations in the background of EZH2 overexpression. We detected no mutation

• br Materials and methods br Results br

  2021-10-14

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either bud H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the receptor´s response

• br Conclusion and future perspectives

  2021-10-14

  

  Conclusion and future perspectives In the setting of myocardial I/R stress, HDAC activity is induced and contributes to myocardial injury. HDAC inhibition appears to protect the lomitapide synthesis from I/R injury by activating a variety of pro-survival molecular pathways. From a clinical relev

• Prolonged sGC oxidative inhibition occurs in many diseases K

  2021-10-14

  

  Prolonged sGC oxidative inhibition occurs in many diseases [46,[86], [87], [88]]. Keeping sGC membrane-bound and functional under conditions of high oxidative stress requires a mechanism for restoring oxidized sGC (Fe3+) heme iron to its reduced (Fe2+) state. Without this redox regulation, the sGC e

• Since TgGC resisted several knockout attempts

  2021-10-14

  

  Since TgGC resisted several knockout attempts with CRISPR-Cas9, we utilized traditional epitope tagging and an auxin-inducible degron (AID) system (Brown et al., 2017, Brown et al., 2018, Long et al., 2017) to detect and regulate TgGC expression. TgGC localizes to the apical cap region of the plasma

• Recent studies on detailed biochemical and structural charac

  2021-10-14

  

  Recent studies on detailed biochemical and structural characterization of plant GSNOR ACSF confirmed their similarities to mammalian homologues [16], [17], [18], [19]. Compared to human GSNOR, plant GSNORs exhibit differences in the composition of the anion-binding pocket, which negatively influenc

15853 records 571/1057 page Previous Next First page 上5页 571572573574575 下5页 Last page