• The effect of on the conformational of

  2022-01-31

  

  The effect of on the conformational of G-quadruplexes was investigated with circular dichroism (CD) spectroscopy. In the absence of , the CD spectra of parallel G-quadruplex exhibited a characteristic positive peak at about 265 nm, and a negative peak at about 240 nm; antiparallel G-quadruplex sh

• Further research should indeed focus

  2022-01-31

  

  Further research should indeed focus on understanding the nutritional value of food and its effect on metabolism, overall activation of metabolic NRs network. Moreover, given the prominent role of microbiota in the modulation of the FXR signalling (Degirolamo et al., 2014), there is enough impetus t

• The repurposing of well characterized and well tolerated dru

  2022-01-31

  

  The repurposing of well-characterized and well-tolerated drugs in order to treat illnesses for which they were not originally intended has emerged as an attractive alternative to a long and costly process of drug development. Repositioning antihistaminergic ligands seems a promising idea given that

• br Acknowledgments br Introduction Lung cancer is

  2022-01-31

  

  Acknowledgments Introduction Lung cancer is a common but extremely perilous cancer, with approximately 733,000 new incidences reported annually in China [1]. Lung cancer ranks highest in the causes of tumor-related mortality, accounting for approximately one quarter of all cancer deaths [2]. N

• p neurotrophin receptor p NTR or CD a member

  2022-01-31

  

  p75 neurotrophin receptor (p75NTR or CD271), a member of the tumor necrosis factor receptor superfamily, has been implicated in several steps of glioma tumorgenesis [5]. p75NTR mediates glioma invasion and progression through γ-secretase-dependent and -independent mechanisms [6], [7], and its expres

• Introduction Heme is an important small molecule and an esse

  2022-01-30

  

  Introduction Heme is an important small molecule and an essential cofactor for a variety of enzymes (George, 1948; Morrison and Stotz, 1954; Maehly, 1952; Igo et al., 1961). During cellular respiration, heme populates cytochromes and serves as an electron acceptor in the electron transport chain (M

• br Financial support This study was supported by Grant PH

  2022-01-30

  

  Financial support This study was supported by Grant PH-102-PP-11, PH-103-PP-11 from the National Health Research Institutes, Taiwan. Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details. Authors’ contributions Acknowledgements Introduction

• Despite the rapid development of synthetic

  2022-01-30

  

  Despite the rapid development of synthetic ligands, the endogenous ligands of GPR109A, GPR109B and GPR81 remained elusive until recently. This is probably the result of their relatively low potencies and their metabolite character (Table 1). Traditionally, agonists of GPCRs were believed to belong t

• Modulation of the cannabinoid system has

  2022-01-30

  

  Modulation of the cannabinoid system has been reported to exert anti-parkinsonian properties through different mechanisms. On one hand, cannabinoids have neuroprotective properties in different rodent models of PD, both through a CB1/CB2 receptor-independent mechanism (Lastres-Becker et al., 2005) a

• It is well known that O tetradecanoylphorbol acetate TPA

  2022-01-30

  

  It is well known that 12-O-tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis in rodents [12]. TPA stimulates a variety of cellular functions in cancer cells, including cell motile activity [13], [14]. In our recent study, when liver epithelial cells were treated

• M 1145 australia A major hurdle in purifying

  2022-01-30

  

  A major hurdle in purifying a membrane protein is finding a detergent that can preserve the protein, after releasing it from a given membrane, in a stable and non-aggregated state during purification steps [18,50]. The ability of various detergents used to solubilize and purify membrane proteins ha

• A localization of GK to both a cytoplasmic

  2022-01-30

  

  A localization of GK to both a cytoplasmic and perinuclear area of normal rat pancreatic beta-cells was reported in 1996 (Noma et al., 1996), which changed on acute hyperglycemia to a more diffuse staining throughout the cytoplasm. The localization of GK within the nucleus was first reported by Mura

• GSK has also been used as PET radiotracer in the

  2022-01-29

  

  GSK-189254 has also been used as PET radiotracer (in the form of [11C]-GSK-189254, also used as [11C]-AZ12807110 by Jucaite et al. (Jucaite et al., 2013)) to assess H3R occupancy (Ashworth et al., 2010), and is currently used in an image-based phase I clinical trial study for investigating GSK-23951

• The Hedgehog signaling pathway HH pathway hereafter is vital

  2022-01-29

  

  The Hedgehog signaling pathway (HH pathway hereafter) is vital for development and tissue homeostasis. [4] In recent years, studying the role of the HH pathway in carcinogenesis and cancer stemness has highlighted the HH inhibitors as putative cancer therapeutics [5]. However, clinical application o

• adenosine triphosphate br Discussion As expected RAS prevale

  2022-01-29

  

  Discussion As expected, RAS prevalence for treatment-experienced patients who failed therapy with first-wave, first-generation drugs telaprevir/boceprevir was higher compared to non-experienced patients likely due to drug-selective pressure. For non-responders to previous therapy, resistance subs

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