Archives
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br Results br Discussion Cell contact mediated spread of
2022-08-15
Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi
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Our data suggest that Slc a is
2022-08-13
Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc
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Introduction Osteoarthritis OA is a prevalent disease charac
2022-08-13
Introduction Osteoarthritis (OA) is a prevalent disease characterized by chronic joint degeneration, including articular cartilage loss, synovitis and osteophyte formation [1], [2], [3], [4], [5]. The cause of OA is metabolic imbalance and mechanical stress, which is coupled with inflammation, lead
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Chitosan CS a deacetylated derivative of
2022-08-13
Chitosan (CS), a deacetylated derivative of chitin, was chosen in this study due to its unique biological characteristics including biodegradability, biocompatibility, non-toxicity, and antimicrobial properties (Klossner, Queen, Coughlin, & Krause, 2008; Kong, Chen, Xing, & Park, 2010; Ravi Kumar, 2
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Structurally the termini of FGF are critical for
2022-08-13
Structurally, the termini of FGF21 are critical for effective signaling. Progressive amino fexofenadine hydrochloride synthesis truncation at either end of the protein sequentially impairs FGF21 bioactivity, but via different mechanisms. Shortening at the N-terminus weakens its ability to activate t
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br Importance of iron and lipoxygenase
2022-08-13
Importance of iron and lipoxygenase in ferroptosis What remains to be somewhat controversial is the role of iron and lipoxygenases (LOX) in the death process, specifically in lipid peroxidation. So far, iron chelators have been repeatedly shown to halt ferroptosis (hence its name) induced by chem
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Compstatin synthesis The comparatively low number of H
2022-08-13
The comparatively low number of H1R agonists is contrasted by the high number of diverse H1R antagonists. Based on pharmacological classification, they are grouped into different generations by considering their target as well as side effects profile. The first generation “antihistamines” consist of
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In this new therapeutic era nucleic acid amplification
2022-08-12
In this new therapeutic era, nucleic Valproic acid amplification tests (NAATs) remain critically useful. NAATs are recommended to detect HCV RNA in blood following initial serologic diagnosis of HCV infection, to distinguish between spontaneous resolution and progression to chronic infection [7]. I
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Mice with GSTP knock out show increased risk of skin
2022-08-12
Mice with GSTP1 knock out show increased risk of skin cancer when exposed to carcinogens like polycyclic aromatic hydrocarbons [23]. Most of the genetic association studies have focused on GSTP1 c.313G > A variant which results in isoleucine to valine substitution at amino Thieno-GTP residue number
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We addressed the role of GSNOR mediated T cell
2022-08-12
We addressed the role of GSNOR-mediated T-cell activation in HHcy-accelerated atherosclerosis in vivo by two mouse models. Generated for the first time, GSNOR-/-ApoE-/- double knock-out mice showed decreased atherosclerosis in aortic roots in response to HHcy. The specificity of GSNOR ablation in T
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br Materials and methods br Results
2022-08-12
Materials and methods Results Discussion The compound P7C3 has been reported to activate NAMPT (Wang et al., 2014) and augment NAD+ levels, thereby promoting the survival of mature neurons and postnatal neurogenesis throughout the post-ischemic Cy3-dCTP (Loris et al., 2017). However, it has
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br Materials and methods br Results
2022-08-12
Materials and methods Results Our data indicated that 1,8-cineol leads to a noticeable but not significant (p = 0.07) 45% decreased phosphorylation of GSK-3α/β at Ser-9/21. Phosphorylation of GSK-3α/β at Tyr-279/216 was not affected (Fig. 1A/B). To ensure, that the decreased phosphorylation of
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Thermal analysis of the NQ peptide was performed
2022-08-12
Thermal analysis of the NQ21 peptide was performed with the Solar CM2203 spectrofluorometer. We prepared three 1 μg/mL peptide solutions with different FIPI levels (5.0, 7.4, 8.5) in 0.01 M phosphate buffers. Each solution was slowly heated up from 28 °C to 54 °C with a step of 1 °C. Spectra were c
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Based on the precedent with other GlyT inhibitors such as
2022-08-12
Based on the precedent with other GlyT1 inhibitors such as , we evaluated both and for their ability to enhance prepulse inhibition (PPI) of the rodent acoustic startle response, a measure of sensorimotor gating known to be deficient in schizophrenic patients., In this 1-Oleoyl lysophosphatidic acid
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Previous studies have suggested that GPR protects from bone
2022-08-12
Previous studies have suggested that GPR40 protects from bone loss via inhibition of osteoclasts. Wittrant et al. used GPR40 knock-out mice and primary osteoclasts to investigate the role of GPR40 on bone remodelling. Their results in primary osteoclast cultures and the RAW264.7 cell line showed tha